We had quite an odd thing happen with this litter. Usually when I am doing breedings we breed the mother every other day between day 10 and 16 of her cycle. With this breeding, we had company stay over and so it was.. well... akward to be breeding dogs. We did one breeding on day 10 and a second breeding on day 16. When the litter was born, we had 3 uniform size puppies, and 2 puppies that seemed pre-mature. The two were always about a week behind the others in size and developement. I think that we litterally got two different litters from the breedings spaced so far apart. All the pups grew and matured normally by adulthood.